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Center projects include two research studies and four development projects. The research projects include R1: An exploratory study to identify the primary cognitive and motivational variables that impact self-management ability and behaviors among adolescents and young adults with neurodevelopmental disabilities; and R2: A randomized clinical trial of a serious game developed to enhance self-management ability among adolescents and young adults with spinal cord dysfunction. The four development projects supported by the Center include: D1: The development of an effective system of data collection, analysis, and display tools to assist healthcare teams support individuals with disabilities to prioritize, address, measure, and track success in achieving personally optimal levels of health and participation; D2: The development of a dynamic scheduling system based on state-of-the-art artificial intelligence (AI) techniques that augments human cognition to support the management of health and participation of young adults with disabilities; D3: The development of a suite of data driven, context-aware and tailorable problem solving tools that leverage mobile and cloud-based technology to assist adolescents and young adults with physical disabilities manage their health in partnership with their care team; and D4: The development of evidence-based strategies, including interactive technology support, for adolescents and young adults with executive dysfunction and neurodevelopmental disabilities to improve self-care strategies, including medication management, medication adherence and side effect assessment. The TIKTOC RERC is an interdisciplinary collaboration of researchers, scientists and clinicians from the School of Medicine, the College of Engineering, the College of Pharmacy, and the School of Information within the University of Michigan.